A narrative review in the Future Healthcare Journal argues the mouth's 700-species bacterial community has been structurally excluded from medicine, despite strong links to type 2 diabetes, cardiovascular disease, and preterm birth, and weaker, associative links to Alzheimer's and cancer.
A national Chinese medical committee has issued a formal clinical guideline covering probiotics, prebiotics, synbiotics, postbiotics and fecal microbiota transplant for patients with metabolic associated fatty liver disease, including detailed FMT donor screening rules.
A gut bacterial metabolite called imidazole propionate (ImP) tracked with lower cognitive scores and more Alzheimer's-related brain biomarkers in nearly 1,200 adults. A genetic analysis and mouse experiments suggest the link may be causal, though modest, and the human findings remain largely observational.
A new study of nearly 3,800 stool samples found two opposing gut-bacteria networks that behave like a seesaw, and a score built from that balance tracked colorectal cancer risk across eight countries, though the authors call it exploratory.
Scientists benchmarked 10 popular gut-microbiome health scores against disease outcomes in over 12,000 people, then tested them in 10 outside cohorts. The most common score, Shannon diversity, didn't survive the trip.
A new Lancet Oncology analysis estimates 2.3 million cancer cases a year, 1 in 8 worldwide, trace back to just five infections, led by the stomach bacterium H. pylori.
A major new analysis in The Lancet Oncology puts a precise number on something doctors have long suspected: roughly one in eight cancers worldwide traces back to a preventable infection. The pathogens involved are familiar, but the scale is striking.
A systematic review pooling 66 studies on gut bacteria and major depressive disorder finds a consistent pattern: less of the bacteria that calm inflammation, more of the bacteria that fuel it, tied to a "leaky gut" pathway into the brain.
A systematic review and meta-analysis of 21 randomized trials in children and adolescents finds that microbiome-targeted interventions like diet, probiotics, prebiotics and fecal transplants produced small reductions in BMI z-score and inflammation, but most other cardiometabolic markers did not budge.
A landmark 2014 study found that gut bacteria follow a roughly 24-hour rhythm paced by meal timing, and that disrupting it via jet lag causes transmissible weight gain and glucose intolerance in mice, with early evidence in humans too.
