A systematic review and meta-analysis of 10 randomized controlled trials found that probiotic supplementation significantly reduced C-reactive protein (CRP) by 0.74 mg/L and tumor necrosis factor-alpha (TNF-alpha) in patients with depression. No significant effects were found for IL-6 or IL-10, and the pooled sample of 486 participants limits confidence in identifying optimal protocols.
A meta-analysis of 11 studies covering 1,175 people with inflammatory bowel disease found small intestinal bacterial overgrowth in nearly 1 in 4, with far higher odds than in people without IBD. Here is what the numbers mean and where the evidence stops.
A meta-analysis of 87 randomized trials found a whole-grain "sweet spot" of 60 to 100 grams a day tied to the biggest drops in weight, cholesterol, blood pressure and inflammation markers.
The Rome Foundation's Rome V update, built by 140+ experts from 27 countries, rewrites how IBS and other disorders of gut-brain interaction are diagnosed, adding new diagnoses and a more flexible clinical-criteria track.
A dose-response meta-analysis of 51 cohort studies and 8.8 million adults links higher ultra-processed food intake to higher risk of seven chronic disease categories, from heart disease to digestive disorders to depression. Researchers propose gut-microbiome disruption as a possible mechanism, but this study did not measure it directly, and as an observational analysis it shows association, not proof of causation.
A massive systematic review found ADHD linked to significantly higher odds of every gastrointestinal symptom studied, though it can't say why.
A new review pulls together decades of research showing antibiotics can disrupt gut bacteria for months to years, raising long-term risk of IBD, obesity, diabetes, and allergies, and lays out what the evidence says actually helps recovery.
A PRISMA-guided meta-analysis reprocessed raw 16S rRNA sequencing data from 11 studies across six countries and found the same inflammatory bacteria — including Porphyromonas and Fusobacterium — consistently enriched in oral squamous cell carcinoma patients, alongside elevated inflammatory genes and a machine-learning signature (AUC 0.84). The findings are associational, drawn from cross-sectional studies, and don't prove these bacteria cause cancer.
In a 1,404-patient randomized trial, two seven-day vonoprazan-based regimens without bismuth matched the cure rate of the standard 14-day H. pylori treatment - though three other shortened regimens fell short, showing that drug pairing, not just duration, decides success.
A new review in Periodontology 2000 traces a biological pathway from chronic gum disease to the brain, finding bacterial toxins in Alzheimer's tissue and a consistently higher dementia risk in people with periodontitis.
